Pathology
Pathology/A/32
Intracranial hemorrhages
頭蓋内出血
- タグ
- Mechanism / 機序High-yield / ポイント
1. Overview
Intracranial hemorrhage is bleeding within the skull; each location has characteristic causes. All are a hemorrhagia per rhexim type — bleeding from a ruptured vessel, due to altered wall pressure or trauma. The four major sites are epidural, subdural, subarachnoid, and intraparenchymal.
| Type | Vessel | Trigger | CT shape / clue |
|---|---|---|---|
| Epidural | Middle meningeal artery | Temporal bone fracture | Lens (biconvex); lucid interval |
| Subdural | Bridging veins | Trauma; brain atrophy | Crescent (concave); slow onset |
| Subarachnoid | Berry aneurysm / AVM | Spontaneous rupture | “Worst headache of life” |
| Intraparenchymal | Charcot–Bouchard microaneurysm | Chronic hypertension | Basal ganglia / thalamus / pons |
2. Apoplexia (intraparenchymal hemorrhage)
- Bleeding into brain parenchyma, related to hypertension (BP >200 mmHg is a rupture risk).
- Rupture of intraparenchymal vessels in the basal ganglia, thalamus, pons.
- Hypertension produces Charcot–Bouchard microaneurysms in small vessels; hyaline arteriolosclerosis makes the wall fragile.
- Bleeding → ↑ ICP → compression of cardiorespiratory centers → tonsillar herniation through the foramen magnum → cardiorespiratory failure → death.
3. Subarachnoid hemorrhage
- Bleeding into the subarachnoid space.
- Non-traumatic rupture of a saccular (berry) aneurysm of cerebral arteries; branching points of the circle of Willis are most aneurysmal.
- Arterial “jet-stream” bleeding → acute ↑ ICP → sudden, excruciating headache.
- A “ticking time bomb” — unpredictable timing; typically presents at 40–50 years as hypertension rises.
4. Subdural hematoma
- Bleeding into the subdural space from torn bridging veins of the dural sinuses.
- Brain atrophy in the elderly stretches these veins, increasing rupture risk (also infants — shaken-baby).
- Two forms:
- Acute — car accidents, sudden trauma.
- Chronic — long-term repeated trauma (boxing) → repeated bleeding → fibrosis around the meninges → neurological symptoms.
5. Epidural hematoma
- Associated with skull fracture. The dura is normally fused tightly to the inner skull (periosteum).
- The middle meningeal artery runs between dura and skull; a temporal bone fracture can rupture it → blood separates dura from periosteum → hematoma compresses the brain.
- Lucid interval — the classic clinical course: unconscious (impact) → conscious recovery → bleeding raises ICP → unconscious again. Alcoholics are more susceptible due to impaired protective reflexes.
💡 High-yield: Epidural = arterial (middle meningeal a.), biconvex/lens shape, lucid interval. Subdural = venous (bridging veins), crescent shape, elderly/atrophy. Subarachnoid = berry aneurysm, thunderclap headache. Intraparenchymal/apoplexia = hypertension + Charcot–Bouchard aneurysms, basal ganglia.