トピック一覧へ
Year 2 · Subject
Molecular Cell Biology
80 notes
011Chemical structure of nucleotides; primary and secondary structure of nucleic acids (DNA and different types of RNA)ヌクレオチドの化学構造;核酸(DNAと各種RNA)の一次構造と二次構造022Condensation of the genetic material in pro- and eukaryotic cells; the role of topoisomerases and chromatin proteins原核・真核細胞における遺伝物質の凝縮;トポイソメラーゼとクロマチンタンパク質の役割033Structure of the human genome: coding and regulatory sequences; noncoding genomic sequences: introns, pseudogenes, repetitive sequences (only for EM-students)ヒトゲノムの構造:コード配列と調節配列;非コードゲノム配列:イントロン・偽遺伝子・反復配列(EM学生のみ)044The role of genetic variations in the pathogenesis of diseases; methods to study genetic factors疾患の病態形成における遺伝的変異の役割;遺伝的因子の研究法055Principles of the semiconservative DNA replication; replication fork, leading and lagging strand synthesis半保存的DNA複製の原理;複製フォーク、リーディング鎖とラギング鎖の合成066Comparison of DNA-replication in pro- and eukaryotes原核生物と真核生物におけるDNA複製の比較077Telomeric repeat sequences: replication of the telomeric regions of eukaryotic chromosomes; functions and importance of the telomeraseテロメア反復配列:真核染色体テロメア領域の複製;テロメラーゼの機能と重要性088The most important types of DNA damage; repair of base deamination (only for EM-students)主要なDNA損傷の種類;塩基脱アミノ化の修復(EM学生のみ)099Formation and repair of thymine dimers; mismatch repair (only for EM-students)チミンダイマーの形成と修復;ミスマッチ修復(EM学生のみ)1010Types of point mutations; mechanisms of their development; possible effects of DNA sequence variations on the corresponding protein点突然変異の種類;その発生機序;DNA配列変異が対応タンパク質に及ぼす影響1111Structure and function of the RNA-polymerase of E. coli; initiation and termination of transcription in prokaryotes大腸菌RNAポリメラーゼの構造と機能;原核生物における転写の開始と終結1212Characterization, role and synthesis of different types of RNA各種RNAの性質・役割・合成1313Regulation of transcription in prokaryotes, definition of operon; positive and negative regulation (only for EM-students)原核生物における転写調節、オペロンの定義;正の調節と負の調節(EM学生のみ)1414Structure of the eukaryotic genes, initiation and termination of transcription in eukaryotes真核生物の遺伝子構造、真核生物における転写の開始と終結1515Regulation of the transcription in eukaryotes (only for EM-students)真核生物における転写調節(EM学生のみ)1616Processing of the eukaryotic mRNA真核生物mRNAのプロセシング1717Function and application of PCR and real-time PCRPCRおよびリアルタイムPCRの機能と応用1818Methods for the investigation of genetic mutations and polymorphisms (RFLP, allele-specific PCR, DNA-sequencing and primer extension)遺伝子変異と多型の検査法(RFLP、アレル特異的PCR、DNAシークエンシング、プライマー伸長法)1919Generation and application of recombinant DNA, reporter- and expression vectors組換えDNAの作製と応用、レポーターベクターと発現ベクター2020Regulation of eukaryotic gene expression at post-transcriptional level (alternative splicing, RNA editing, regulation of RNA stability, RNA quality control) (only for EM-students)転写後レベルでの真核生物遺伝子発現の調節(選択的スプライシング、RNA編集、RNA安定性の調節、RNA品質管理)(EM学生のみ)2121Regulation of eukaryotic gene expression by RNA interference (miRNA, siRNA)RNA干渉による真核生物遺伝子発現の調節(miRNA、siRNA)2222Epigenetic regulation of eukaryotic transcription: the role of DNA methylation and histone modifications真核生物転写のエピジェネティック調節:DNAメチル化とヒストン修飾の役割2323The genetic code; structure and function of tRNAs; aminoacyl-tRNA synthetases; codon-anticodon connections遺伝暗号;tRNAの構造と機能;アミノアシルtRNA合成酵素;コドン-アンチコドンの対応2424The structure of prokaryotic and eukaryotic ribosomes; the ribosome cycle; binding of tRNA to ribosomes原核・真核リボソームの構造;リボソームサイクル;tRNAのリボソームへの結合2525Initiation of the translation in pro- and eukaryotes; regulation of eukaryotic translation; the role of phosphorylation of eIF2α原核・真核生物における翻訳開始;真核生物翻訳の調節;eIF2αリン酸化の役割2626Elongation and termination of pro- and eukaryotic translation; pharmacological inhibitors of translation原核・真核生物翻訳の伸長と終結;翻訳の薬理学的阻害薬2727Post-translational modifications of proteinsタンパク質の翻訳後修飾2828Types, structure and synthesis of collagenコラーゲンの種類・構造・合成2929Investigation of gene expression by real-time PCR and DNA-microarray methodologyリアルタイムPCRおよびDNAマイクロアレイ法による遺伝子発現の解析3030Definition of proteostasis; types of intracellular protein degradationプロテオスタシスの定義;細胞内タンパク質分解の種類3131Structure and function of the proteasome; role of immune-proteasome and TAP (only for EM-students)プロテアソームの構造と機能;免疫プロテアソームとTAPの役割(EM学生のみ)3232Types, mechanism and role of autophagyオートファジーの種類・機構・役割3333Lytic and lysogenic replication cycles of bacteriophages (only for EM-students)バクテリオファージの溶菌サイクルと溶原サイクル(EM学生のみ)3434Classification of animal viruses; structure and replication of retroviruses (only for EM-students)動物ウイルスの分類;レトロウイルスの構造と複製(EM学生のみ)3535Principles of human gene therapy (in vivo vs. ex vivo methods, gene augmentation, CRISPR/Cas9 system) (only for EM-students)ヒト遺伝子治療の原理(in vivo法とex vivo法、遺伝子付加、CRISPR/Cas9システム)(EM学生のみ)3636Biomedical application of genetic engineering processes (transgenic animals; knock-out, knock-in and knock-down techniques; cloning) (only for EM-students)遺伝子工学の生物医学的応用(トランスジェニック動物;ノックアウト・ノックイン・ノックダウン技術;クローニング)(EM学生のみ)3737Nuclear receptors: steroid, thyroid, retinoid and Ah receptors核内受容体:ステロイド・甲状腺・レチノイド・Ah受容体3838Classification and function of membrane receptors膜受容体の分類と機能3939Types and functions of GTP-binding proteins in signalingシグナル伝達におけるGTP結合タンパク質の種類と機能4040Activation mechanisms of serine / threonine protein-kinases with examplesセリン/スレオニンタンパク質キナーゼの活性化機構と例4141cAMP signaling pathway; regulation of gene expression by cAMPcAMPシグナル伝達経路;cAMPによる遺伝子発現の調節4242Phosphatidylinositol signaling pathwaysホスファチジルイノシトールシグナル伝達経路4343NFκB and TGFβ signalingNFκBおよびTGFβシグナル伝達4444Structure and function of tyrosine kinase receptors, the Erkl / Erk2 MAP kinase cascadeチロシンキナーゼ受容体の構造と機能、Erk1/Erk2 MAPキナーゼカスケード4545Insulin signalingインスリンシグナル伝達4646Integrating role of mTOR, and its effects on translationmTORの統合的役割と翻訳への影響4747Role of AMPK in the regulation of the metabolism and autophagy代謝とオートファジーの調節におけるAMPKの役割4848Mechanisms of cellular oxygen sensing; adaption to hypoxia細胞の酸素感知機構;低酸素への適応4949Regulation of the cell cycle in the G1 phase, transition to S phaseG1期における細胞周期の調節、S期への移行5050Regulation of the cell cycle in the G2 and M phasesG2期およびM期における細胞周期の調節5151Molecular sensors detecting DNA damage and completion of DNA replication during the cell cycle細胞周期におけるDNA損傷とDNA複製完了を検知する分子センサー5252Molecular background of tumor generation腫瘍発生の分子的背景5353Structure and function of the apoptosome, DISC and PIDDosome complexesアポトソーム・DISC・PIDDソーム複合体の構造と機能5454Members of the Bcl-2 superfamily and their roles in various apoptotic pathways, the „survival signal”Bcl-2スーパーファミリーの構成因子とさまざまなアポトーシス経路における役割、「生存シグナル」5555Function and activation of apoptotic caspases, role of granzyme Bアポトーシス性カスパーゼの機能と活性化、グランザイムBの役割5656Types of non-apoptotic programmed cell death (only for EM-students)非アポトーシス性のプログラム細胞死の種類(EM学生のみ)5757Regulation of p53 levels and activity; role of p53 in determining the cell’s fatep53の量と活性の調節;細胞運命決定におけるp53の役割5858Molecular mechanisms involved in aging (only for EM-students)老化に関わる分子機構(EM学生のみ)5959Principles of the organization of the eukaryotic cells; compartmentation; main features of subcellular organelles真核細胞の構成原理;区画化;細胞内小器官の主な特徴6060Structure of cytoskeleton; structure and function of motor proteins細胞骨格の構造;モータータンパク質の構造と機能6161The protein secretory pathway; role of the rab cycle in the regulation of vesicular transportタンパク質分泌経路;小胞輸送の調節におけるRabサイクルの役割6262Endo- and exocytosisエンドサイトーシスとエキソサイトーシス6363Formation of the proteome of subcellular organelles; principles and mechanisms of protein sorting (only for EM-students)細胞内小器官のプロテオーム形成;タンパク質選別の原理と機構(EM学生のみ)6464Protein targeting in the secretory pathway (only for EM-students)分泌経路におけるタンパク質ターゲティング(EM学生のみ)6565Protein targeting into mitochondria and peroxisomes; uptake of substrates into lysosomes (only for EM-students)ミトコンドリアとペルオキシソームへのタンパク質ターゲティング;リソソームへの基質取り込み(EM学生のみ)6666Nuclear import and export of macromolecules (only for EM-students)高分子の核内輸送と核外輸送(EM学生のみ)6767Endoplasmic reticulum stress, connection between the Unfolded Protein Response (UPR) and apoptosis小胞体ストレス、小胞体ストレス応答(UPR)とアポトーシスの関連6868Protein quality control in the endoplasmic reticulum; the fate of misfolded proteins; ERAD小胞体におけるタンパク質品質管理;ミスフォールドタンパク質の運命;ERAD6969Characteristics of the metabolome of subcellular organelles; maintenance of the internal milieu of subcellular organelles細胞内小器官のメタボロームの特徴;細胞内小器官の内部環境の維持7070Role of the extracellular matrix in signal transduction (e.g., integrin receptors), role of the extracellular matrix in the formation of metastasis (only for EM-students)シグナル伝達における細胞外マトリックスの役割(例:インテグリン受容体)、転移形成における細胞外マトリックスの役割(EM学生のみ)7171Methods in cell biology: cell culturing, cell fractionation, in vivo microscopy, flow cytometry, FACS (only for EM-students)細胞生物学の手法:細胞培養、細胞分画、in vivo顕微鏡観察、フローサイトメトリー、FACS(EM学生のみ)7272Quantification of proteins by biuret reaction and Ellmann-methodビウレット反応とエルマン法によるタンパク質の定量7373Investigation of subcellular cell fractions細胞内分画の解析7474Investigation of the gene expression in prokaryotes: induction of β-galactosidase in E. coli原核生物における遺伝子発現の解析:大腸菌でのβ-ガラクトシダーゼの誘導7575Purification of a bacterially expressed protein by affinity chromatographyアフィニティークロマトグラフィーによる細菌発現タンパク質の精製7676SDS-polyacrylamide gel electrophoresis and Western blotSDSポリアクリルアミドゲル電気泳動とウェスタンブロット7777In silico tools in molecular biology分子生物学におけるin silicoツール7878Genotyping of the TAS2R38 tasting receptor by PCR-RFLPPCR-RFLPによるTAS2R38味覚受容体の遺伝子型判定7979Analysis and generation of a recombinant DNA組換えDNAの解析と作製8080In vitro transcription and translationin vitro転写・翻訳